Re: Macrophage role in the anti-prostate cancer response to one class of antiangiogenic agents.
نویسندگان
چکیده
As reported in a recent article in the Journal, Joseph and Isaacs (1) tried to combine Linomide® with other antiangiogenic agents known to inhibit tumorassociated macrophages (TAMs) to evaluate their joint antitumor effects. Unfortunately, the combination of Linomide with other antiangiogenic agents did not result in potentiation of therapeutic efficacy. Instead, one of these agents, pentoxifylline, inhibited the an-
منابع مشابه
Macrophage role in the anti-prostate cancer response to one class of antiangiogenic agents.
BACKGROUND Tumor-associated macrophages (TAMs) can either promote angiogenesis (i.e., the formation of new blood vessels) in tumors by secreting tumor necrosis factor-alpha (TNF-alpha) or inhibit angiogenesis by producing granulocyte-macrophage colony-stimulating factor (GM-CSF), which in turn stimulates production of the antiangiogenic protein plasminogen activator inhibitor type 2 (PAI-2). We...
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ورودعنوان ژورنال:
- Journal of the National Cancer Institute
دوره 91 9 شماره
صفحات -
تاریخ انتشار 1999